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Whatever the community, wherever in the world, frequent and correct hand hygiene helps prevent the spread of COVID-19 and other diseases. However, across the globe communities may (for reasons of geography, social determinants of health or political situations) lack the access to knowledge and/or resources to most ensure effective and universal handwashing to prevent the spread of diseases and viruses like COVID-19. Knowledge is best transferred in culturally appropriate and sensitive ways as defined by the end users and community being served. Resources required include access to potable water, soap and/or approved disinfectants. For caregivers and health care providers, required resources may also include personal protective equipment (PPE).